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Ketamine

Adult Psychiatry located in Fort Collins, CO
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Ketamine services offered in Fort Collins, CO


Ketamine is a new treatment tool that offers relief for about 70% of people who don’t respond to antidepressants. Foremost psychiatrist Josiah Ziegler, DO, has seen the remarkable effects of ketamine in many of his patients at Psychiatric Services of the Rockies. As a trailblazer in the psychiatric field, Dr. Ziegler offers ketamine treatment options through telemedicine and office-based appointments in Fort Collins, Colorado. Call the office or use the provided booking feature to schedule your consultation and evaluation now.

Ketamine Q&A

What is ketamine?

Ketamine is a drug that gained FDA approval more than 50 years ago. Originally, it was used only during surgery as a safe and reliable anesthetic because it doesn’t depress breathing as many other anesthetics do. 

More recently, ketamine has garnered attention for having rapid effects within the brain of people who have depression and other mental illnesses. In many cases, it provides near-instant relief.

How does ketamine affect the brain?

Ketamine works on the neurotransmitters, the brain chemicals that influence your mood. That might sound familiar if you’ve ever taken antidepressants, and it’s true that those drugs also work on neurotransmitters. 

But while antidepressants usually impact serotonin levels, low doses of ketamine ultimately cause a flood of glutamate, which is often called the “master” neurotransmitter. This has a rapid antidepressant effect. 

Ketamine works in other ways, too, which researchers don’t fully understand. Currently thinking is that it causes the release of additional chemicals that work like neural fertilizers.

Basically, those chemicals cause new brain neuron connections to spring up. This allows for the development of new healthy thought pathways that can replace the old (harmful) ones.

These unique effects help explain ketamine’s effectiveness when people taking oral antidepressants showed no improvement.

Ketamine therapy has led to impressive results in people with depression, anxious depression (depression plus severe anxiety), obsessive-compulsive disorder (OCD), bipolar disorder, and post-traumatic stress disorder (PTSD).

A recent major study conducted over a four-year period concluded that ketamine provided powerful immediate relief of symptoms in suicidal patients. Many patients were in full remission within three days, and it continued for six weeks or longer in most cases.   

What is the ketamine treatment process?

The many methods of ketamine treatment include:

  • Nasal spray (Spravato®)
  • Oral lozenges
  • Intravenous infusions
  • Injections

Spravato is FDA-approved as a treatment for depression that doesn’t improve with the use of two or more antidepressants, known as treatment-resistant depression (TRD). The other methods aren’t yet FDA-approved, but many psychiatrists administer ketamine to patients who are fighting challenging mental health battles. 

Many services, including medication management and mental therapy, are available through telemedicine. But some initial psychiatric evaluations and treatments, like ketamine infusions, require office visits. 

To find out if ketamine can work for you, call Psychiatric Services of the Rockies or click the online booking feature now.

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